Prognostic value of platelet indices and platelet-to-albumin ratioin assessing disease activity in crohn’s disease
DOI:
https://doi.org/10.63583/hw1h2d63Từ khóa:
Crohn’s Disease (CD); platelet count (PLT); mean platelet volume (MPV); plateletcrit (PCT); Simple Endoscopic Score for Crohn Disease (SES-CD), albumin (ALB).Tóm tắt
Objective: to evaluate the prognostic value of selected platelet indices and platelet-to-albumin ratio in predicting disease activity in Crohn's disease. Subject and method: A cross-sectional descriptive study on 85 patients diagnosed with Crohn's disease at 108 Military Central Hospital from October 2021 to April 2025. Result: The mean age of participants was 37.14 ± 15.15 years; 63.5% were male. The age of disease onset was predominantly between 17 and 39 years (64.7%). The most common clinical symptoms were digestive disorders (89.4%) and abdominal pain (80%). The most frequent complications were fistula (32.9%) and stricture (23.5%). The platelet count (PLT), plateletcrit (PCT), and PLT/ALB ratio were significantly higher in the active Crohn’s disease group compared to the remission group (p < 0.01). These indices were also significantly correlated with the SES-CD score. PCT and the PLT/ALB ratio were found to be better biomarkers for predicting disease activity. The optimal cut-off value for PCT was 0.244, with a sensitivity of 86.6% and a specificity of 72.2%; the area under the curve (AUC) was 0.797 (p < 0.01). For the PLT/ALB ratio, the cut-off value was 7.80, with a sensitivity of 79.3%, specificity of 72.2%, and an AUC of 0.792 (p < 0.01). Conclusion: PCT and the PLT/ALB ratio, which depend on platelet count, mean platelet volume (MPV), and albumin levels, may serve as independent indices and sensitive biomarkers for identifying active Crohn's disease.
Tài liệu tham khảo
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